Exercise Creates Structural Stress

Now, the other kind of stress Structural stress from activity that physical activity cause is structural stress. Now, when I was running this morning, for example, my mitochondria were generating all kinds of ATP to fuel my body, but my mitochondria were also spewing out all kinds of reactive oxygen species, which cause widespread damage throughout my body. I was getting mutations in my DNA, those that damage is causing my telomeres at the end of my chromosomes to shorten its damaging cells. ...

 Seeing Organizations as Biological Systems

There’s a continuing struggle between complexity and robustness in both evolution and human design. A kind of survival imperative, whether in biology, engineering, or business requires that simple, fragile systems become more robust. But the mechanisms to increase robustness will in turn make the system considerably more complex. Furthermore, that additional complexity brings with it its own unanticipated failure modes, which are corrected over time with additional robust mechanisms, which ...

 Heritable IQ is Boosted by Environment, Just Like Height

hough it’s not easy to pinpoint the causes of the rise in IQ scores, it’s no paradox that a heritable trait can be boosted by changes in the environment. That’s what happened with height, a trait that also is highly heritable and has increased over the decades, and for some of the same reasons: better nutrition and less disease. Brains are greedy organs, consuming about a fifth of the body’s energy, and they are made of fats and proteins that are demanding for the body to produce. Fig...

 Adult Physical Activity Keeps Immune System Young

It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (55–79 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age-matched older adults and ...

 The Need for Science-Based Organization

Some time shortly after the invention of the graphical Internet, it became ripely apparent that humanity was fucking itself with its own technology and was on the fast path toward societal morbidity. We maximized energy extraction without perfecting clean use, accelerated manufacturing technologies and global supply chains without developing socioeconomic models to cope with the disruptions, and modified life itself without having any perspective on what modifications would actually, in the ...

 Political Detox - Why Political Discussions Become Disres...

For one week, political stories are off-topic. Please flag them. Please also flag political threads on non-political stories. For our part, we'll kill such stories and threads when we see them. Then we'll watch together to see what happens. Why? Political conflicts cause harm here. The values of Hacker News are intellectual curiosity and thoughtful conversation. Those things are lost when political emotions seize control. Our values are fragile—they're like plants that get forgotten, then ...